Research advances in the relationship between chronic endometritis and uterine diseases
10.3760/cma.j.cn101721-20250123-00047
- VernacularTitle:慢性子宫内膜炎与子宫疾病关系的研究进展
- Author:
Dan LI
1
;
Yuan YANG
1
Author Information
1. 兰州大学第一医院生殖医学中心，兰州 730000
- Publication Type:Journal Article
- Keywords:
Endometritis;
Uterine diseases;
Reproductive health
- From:
Clinical Medicine of China
2025;41(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
Chronic endometritis (CE) is a persistent and insidious inflammation of the endometrium caused by various pathogens. Most patients exhibit mild or no apparent symptoms, leading to frequent underdiagnosis in clinical practice. However, CE has gained significant attention due to its association with reduced endometrial receptivity, interference with embryo implantation, and increased risks of pregnancy-related complications, including miscarriage, premature rupture of membranes, preterm birth, and intrauterine infections. The relationship between CE and common uterine pathologies remains unclear, and research in this area is still in its early stages. Previous research suggests that in endometrial polyp (EP) patients, CE may promote polyp formation by inducing a local inflammatory microenvironment and significantly elevate postoperative recurrence rates. The incidence of CE is notably higher in endometriosis (EMs) patients compared to healthy individuals. Postoperative adhesion recurrence rates rise substantially for intrauterine adhesion patients with concurrent CE. The high prevalence of CE in submucosal fibroid cases suggests that chronic inflammation may drive fibroid pathogenesis via abnormal activation of stromal stem cells. The co-occurrence of adenomyosis and CE suggests that inflammatory microenvironments may harm the endometrial-myometrial interface, facilitating ectopic gland infiltration. Additionally, in CE combined with endometrial hyperplasia (EH), inflammation-mediated dysregulation of cell cycle markers may heighten the risk of malignant transformation.
