Research Progress of Adoptive Cell Immunotherapy in Ovarian Cancer

VernacularTitle:过继性细胞免疫治疗在卵巢癌中的研究进展
Author: Xiaoxia JIANG ¹ ; Yujie HAO ¹ ; Xianghong PU ¹ ; Jiangsha LI ¹ ; Zheng LI ¹
Author Information

1. 云南省肿瘤医院/昆明医科大学第三附属医院/北京大学肿瘤医院云南医院,云南昆明 650118
Publication Type:Journal Article
Keywords: adoptive cell immunotherapy; ovarian cancer; clinical research advances; combina-tion therapy strategies
From: China Cancer 2025;34(6):491-497
CountryChina
Language:Chinese
Abstract: Ovarian cancer has the highest mortality rate in female malignant tumors of reproduc-tive system,with high recurrence rate and secondary resistance to platinum-containing chemotherapy.In recent years,adoptive cell immunotherapy(ACT),as an emerging immunotherapeutic strategy,shows great potential in the treatment of ovarian cancer.Although the immunosuppressive microenvironment and limited target selection are still the main challenges facing the current ACT treatment for ovarian cancer,it is still expected that the efficacy of ACT in ovarian cancer patients can be further improved by optimizing the cell production techniques and combining multiple thera-peutic approaches.This paper aims to provide a reference for the development of innovative thera-pies for ovarian cancer by reviewing the latest research progress on the mechanism and application of ACT therapy in ovarian cancer.