Clinical observation of Jiawei Ditan decoction in the treatment of acute cerebral infarction of phlegm and stasis obstruction type and its effect on serum inflammatory factors
10.3969/j.issn.1673-9701.2025.15.013
- VernacularTitle:加味涤痰汤治疗痰瘀阻络型急性脑梗死的临床观察及对血清炎症因子的影响
- Author:
Yiwei ZHANG
1
;
Qingjin HUANG
;
Hui LIANG
Author Information
1. 福建中医药大学附属人民医院脑病科,福建 福州 350004
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction;
Jiawei Ditan decoction;
Phlegm and stasis obstruction type;
Inflammatory factors
- From:
China Modern Doctor
2025;63(15):61-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Jiawei Ditan decoction in the treatment of patients with acute cerebral infarction(ACI)with phlegm and stasis obstruction type and its effect on serum inflammatory factors.Methods From August 2022 to January 2024,60 patients with phlegm and stasis obstructed type ACI who were hospitalized in the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine were selected and randomly divided into control group and observation group,30 cases in each group.The control group received the conventional Western medicine treatment program,while the observation group was intervened on the basis of control group with the addition of Jiawei Ditan decoction.After 2 weeks of treatment,the efficacy and mechanism of action with ACI patients were evaluated by traditional Chinese medicine syndrome score,National Institute of Health stroke scale(NIHSS),modified Barthel index(MBI),and serum matrix metalloproteinase-9(MMP-9),interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP),and homocysteine(Hcy)levels.Results After treatment,traditional Chinese medicine syndrome improvement in observation group demonstrated a markedly greater total efficacy rate than that in control group,with statistical significance(P<0.05).Both groups showed improvements in NIHSS and MBI scores compared to pre-treatment levels,with observation group demonstrating more significant improvements(P<0.05).Additionally,post-intervention,MMP-9,IL-6,hs-CRP,and Hcy levels showed a decline in both groups,with a more significant decrease observed in observation group(P<0.05).Conclusion Jiawei Ditan decoction may effectively reduce the inflammatory response of phlegm stasis obstructive type ACI by down-regulating the serum levels of MMP-9,IL-6,hs-CRP and Hcy,thereby improving neurological deficits and improving patients'daily living ability,which has certain clinical application value.
