The value of cuprotosis-related gene CDKN2A in the diagnosis of chronic obstructive pulmonary disease induced by cigarette smoke
10.3969/j.issn.1673-9701.2025.15.008
- VernacularTitle:铜死亡相关基因CDKN2A在诊断香烟烟雾诱导的慢性阻塞性肺疾病中的价值
- Author:
Yu TAN
1
;
Lingfeng MIN
1
Author Information
1. 扬州大学附属苏北人民医院呼吸与危重症医学科,江苏 扬州 225001
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Cuprotosis-related gene;
Cigarette smoke;
Cyclin-dependent kinase inhibitor 2A
- From:
China Modern Doctor
2025;63(15):35-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of cuprotosis-related genes in the diagnosis and disease progression of chronic obstructive pulmonary disease(COPD).Methods Differential gene expression related to COPD was identified through gene expression omnibus series(GSE)10006,GSE11784,GSE19407,and GSE8545 datasets,and compared with previously identified cuprotosis-related genes to identify differentially expressed genes.Weighted gene co-expression network analysis(WGCNA)was then performed on GSE8545 and GSE19407 datasets to explore the correlation between cuprotosis-related genes and COPD phenotypes.GSE20257 dataset was introduced to validate the gene's expression level changes and further investigate the impact of smoking on gene expression levels.Subsequently,the effects of smoking cessation on gene expression levels were explored by using the GSE7895 datasets.GSE162635 dataset was then utilized to investigate the impact of differentially expressed cuprotosis-related genes on the severity of COPD.Results The study identified cyclin-dependent kinase inhibitor 2A(CDKN2A)as a potential cuprotosis-related gene associated with COPD,confirming that smoking upregulated CDKN2A expression in lung tissue,which returns to baseline levels after smoking cessation.Finally,the study confirmed that the expression level of CDKN2A was associated with the prognosis of COPD,increasing with severity.Conclusion The study identifies CDKN2A as a cuprotosis-related gene associated with COPD,and shows promising diagnostic potential and correlation with disease severity.
