Clinical efficacy and mechanism of Zishen Shujing Decoction in treating premature ovarian failure with kidney deficiency and liver depression
10.3969/j.issn.1673-9701.2025.14.012
- VernacularTitle:滋肾舒经汤治疗肾虚肝郁型卵巢早衰临床疗效及机制
- Author:
Ziqiong ZHOU
1
;
Xuelian DU
;
Jianmei HUANG
;
Shuyi LING
;
Yuehui ZHENG
Author Information
1. 广州中医药大学 广州中医药大学第四临床医学院妇科,广东 深圳 518033;广州中医药大学 广州中医药大学第四临床医学院生殖科,广东 深圳 518033
- Publication Type:Journal Article
- Keywords:
Premature ovarian failure;
Zishen Shujing decoction;
Kidney deficiency and liver depression type;
Immune inflammation
- From:
China Modern Doctor
2025;63(14):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Zishen Shujing decoction in the treatment of kidney deficiency and liver depression type premature ovarian failure(POF).Methods A total of 70 female POF patients who visited the Fourth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine from July 2023 to April 2024 were selected as the research subjects,they were divided into traditional Chinese medicine(TCM)treatment group(n=35)and Western medicine treatment group(n=35)by using a random number table method.Western medicine treatment group was treated with femostone,and TCM treatment group was treated with Zishen Shujing decoction.Differences of TCM syndrome scores and clinical efficacy were compared between two groups before and after treatment,and changes of peripheral blood follicle-simulating hormone(FSH),anti-Müllerian hormone(AMH),anal follicle count(AFC)and interleukin(IL)-4,IL-6 before and after treatment were compared.Results The effective rate of TCM treatment group was higher than that of Western medicine treatment group,the difference was statistically significant(P<0.05).The TCM syndrome scores after treatment were lower than before treatment,and TCM treatment group was lower than Western medicine treatment group,the difference was statistically significant(P<0.05).After treatment,FSH levels in two groups were lower than before treatment,AMH and AFC levels were higher than before treatment,and improvement of hormone levels,AMH and AFC in TCM treatment group was better than that in Western medicine treatment group,with statistical significance(P<0.05).After treatment,the anti-inflammatory factors IL-4 were increased,and the pro-inflammatory factors IL-6 were decreased,and the increase effect of anti-inflammatory factors and the decrease effect of pro-inflammatory factors in TCM treatment group were better than those in Western medicine treatment group with statistical significance(P<0.05).Conclusion Zishen Shujing decoction can improve the clinical symptoms,serum hormone levels of POF patients with kidney deficiency and liver depression,improve ovarian function,reduce immune inflammation,reduce oxidative stress,and effectively improve the quality of life of patients.
