Recurrence mechanisms and treatment strategies for IDH wild-type glioblastoma
10.12354/j.issn.1000-8179.2025.20250044
- VernacularTitle:IDH野生型胶质母细胞瘤复发机制与治疗策略
- Author:
Tao WANRU
1
;
Lv LEI
;
Wang ZIJUN
;
Bao LEILEI
Author Information
1. 上海理工大学健康科学与工程学院(上海市 200093);海军军医大学第三附属医院药剂科
- Publication Type:Journal Article
- Keywords:
isocitrate dehydrogenase(IDH);
glioblastoma;
recurrence mechanism
- From:
Chinese Journal of Clinical Oncology
2025;52(6):309-313
- CountryChina
- Language:Chinese
-
Abstract:
Isocitrate dehydrogenase(IDH)wild-type glioma is a type of highly invasive brain tumor with poor prognosis and a high recur-rence rate.The recurrence process is driven by multiple complex and interwoven factors.Although the current standard treatment regi-mens can temporarily alleviate patients'symptoms,they still face significant challenges in effectively preventing tumor recurrence.The re-currence mechanism of this tumor is intricate and covers multiple aspects such as genomic instability,maintenance of stem cell characterist-ics and mesenchymal transformation,as well as dynamic changes in the tumor microenvironment.This article aims to comprehensively sum-marize the recurrence mechanism of glioblastoma and deeply explore potential countermeasures targeting these mechanisms,hoping to open up new perspectives and approaches for the treatment of recurrent tumors.
