Advances in molecular subtyping of small cell lung cancer and exploration of precision therapy strategies
10.12354/j.issn.1000-8179.2025.20250237
- VernacularTitle:小细胞肺癌分子分型的研究进展与精准治疗的策略探索
- Author:
Feng YUCHAO
1
;
Cao XIAOHONG
Author Information
1. 山西医科大学汾阳学院(山西省汾阳市 032200)
- Publication Type:Journal Article
- Keywords:
small cell lung cancer(SCLC);
molecular subtype;
neuroendocrine carcinoma;
precision treatment
- From:
Chinese Journal of Clinical Oncology
2025;52(7):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Small cell lung cancer(SCLC)is a highly malignant neuroendocrine tumor,which is prone to metastasis and is associated with a very poor prognosis.SCLC was previously regarded as a homogeneous disease that lacked individualized treatment strategies.In recent years,molecular typing studies have revealed the high heterogeneity of SCLC.However,issues such as inconsistent typing standards,the dy-namic transformation of subtypes,and complex drug resistance mechanisms restrict the clinical translation of the results.This article sys-tematically expounds the research progress of SCLC molecular typing,summarizes its potential and challenges in driving precision treatment,and aims to provide ideas for the development of precise medical treatment plans and promote the clinical translation of the"typing-guided treatment"model for SCLC.
