Functional study of M1/M2 macrophages in the progression of oral squamous cell carcinoma

VernacularTitle:M1/M2型巨噬细胞影响口腔鳞癌进展的功能研究
Author: Xu XIAOYI ¹ ; Wang BIN ; Yang MENGMENG ; Shen JUN
Author Information

1. 天津市人民医院,南开大学第一附属医院口腔科(天津市 300121)
Publication Type:Journal Article
Keywords: oral squamous cell carcinoma(OSCC); tumor-associated macrophages(TAMs); M1 macrophage; M2 macrophage
From: Chinese Journal of Clinical Oncology 2025;52(7):325-330
CountryChina
Language:Chinese
Abstract: Objective:This study aimed to identify potential prognostic and biotherapeutic targets for oral squamous cell carcinoma(OSCC)by investigating the regulatory effects of M1/M2 macrophages on OSCC progression and their underlying mechanisms.Methods:The ef-fects of M1/M2 macrophages on the proliferation,migration,invasion,and apoptosis of SCC-15 cells were examined.Immunohistochemical staining was used to detect the expression of CD68 and M2 macrophage marker proteins in human OSCC tissue microarrays,and their cor-relations with clinicopathological features were analyzed.Results:M1 macrophages promoted apoptosis of SCC-15 cells while inhibiting their proliferation,migration,and invasion.In contrast,M2 macrophages exhibited the opposite effects.The infiltration density of tumor-associ-ated macrophages(TAMs)in OSCC tissues was significantly positively correlated(P<0.05)with lymph node metastasis.Conclusions:M1 mac-rophages suppress OSCC progression,whereas M2 macrophages promote it.