Current status of clinical research on preoperative neoadjuvant therapy for locally ad-vanced esophageal cancer
10.12354/j.issn.1000-8179.2025.20250086
- VernacularTitle:局部晚期食管癌术前新辅助治疗临床研究现状
- Author:
Zhang JUANJUAN
1
;
Huang DABING
Author Information
1. 蚌埠医科大学(安徽省 蚌埠市 233030)
- Publication Type:Journal Article
- Keywords:
locally advanced esophageal cancer;
neoadjuvant therapy;
squamous cell carcinoma;
adenocarcinoma
- From:
Chinese Journal of Clinical Oncology
2025;52(7):366-371
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer is a malignant tumor of the digestive tract,with squamous cell carcinoma and adenocarcinoma accounting for over 99%of cases.Most patients are diagnosed at a locally advanced stage,and the efficacy of surgery alone is unsatisfactory.To improve the survival rate of patients with locally advanced esophageal cancer,researchers have explored a comprehensive treatment model based on neoadjuvant therapy,including neoadjuvant chemotherapy,neoadjuvant chemoradiotherapy,neoadjuvant immunochemotherapy,and neoadjuvant immunotherapy combined with chemoradiotherapy.Due to the differences in treatment sensitivity between squamous cell carcinoma and adenocarcinoma,this article systematically reviewed the response characteristics of different pathological types of esopha-geal cancer to neoadjuvant therapy using the latest clinical research data.
