Establishment and clinical applications of a prognostic model based on disease progression within 24 months in patients with multiple myeloma
10.12354/j.issn.1000-8179.2025.20241435
- VernacularTitle:基于24个月内疾病进展的多发性骨髓瘤患者预后模型的建立及临床应用
- Author:
Gong YINGYING
1
;
Cao YONGQIN
;
Xia JUN
;
Wang QINGQING
;
Sun CHAO
Author Information
1. 南京医科大学附属无锡人民医院血液科,无锡市人民医院,南京医科大学无锡医学中心(江苏省 无锡市 214023);苏州大学附属第一医院血液科
- Publication Type:Journal Article
- Keywords:
multiple myeloma(MM);
disease progression within 24 months(POD24);
prognostic analysis;
prognostic model
- From:
Chinese Journal of Clinical Oncology
2025;52(3):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a prognostic model and explore its clinical application based on disease progression within 24 months(POD24)in patients with multiple myeloma(MM).Methods:A total of 289 patients newly diagnosed with MM at Wuxi People's Hospital from January 2007 to June 2022 were selected as the training group for retrospective analysis.A prognostic model based on POD24 was constructed using Cox univariate and multivariate analyses of overall survival(OS).A total of 184 patients from The First Affiliated Hospital of Soochow University from August 2015 to December 2019 were included in the validation group to verify the predictive efficacy of the model.Results:Age,β2-microglobulin,Calcium,and POD24 were independent prognostic factors for MM.Patients in the high-risk group(≥2 points)had shorter OS(25.0 months vs.60.0 months)and progression-free survival(PFS)(14.0 months vs.56.0 months)than those in the low-risk group(<2 points).In addition,OS and PFS differed between the high-and low-risk groups in the entire validation group,as well as in each patient subgroup(P<0.05).Conclusions:The prognostic model based on POD24,age,β2 microglobulin,and Calcium holds prognostic value for patients newly diagnosed with MM in clinical practice.
