Research progress on the role of tertiary lymphoid structures in cancer therapy

VernacularTitle:三级淋巴结构在肿瘤治疗中的研究进展
Author: Yan HUIYING ¹ ; Li HUIKAI ¹
Author Information

1. 天津医科大学肿瘤医院肝胆肿瘤科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室(天津市 300060)
Publication Type:Journal Article
Keywords: tertiary lymphoid structures(TLSs); tumor; therapy
From: Chinese Journal of Clinical Oncology 2025;52(3):149-153
CountryChina
Language:Chinese
Abstract: Uncoated ectopic tertiary lymphoid structures(TLSs)are found at sites of chronic inflammation and consist primarily of germinal centers(GCs),peripheral T-cell areas,and high endothelial venules(HEVs).TLSs are typically formed during conditions causing chronic in-flammation,such as infections,autoimmune disorders,tissue transplantation,and cancer.With immunotherapy at the forefront of cancer treatment strategies,effective biomarkers for immunotherapy have gained significant research attention.In recent years,several studies have shown that TLSs can improve the efficacy of immunotherapy;therefore,TLSs can be used as specific biomarkers for immune check-point inhibitors(ICIs).In this review,we discuss the development of TLSs,their role in the tumor immune microenvironment,and their therapeutic significance as biomarkers.