Multivariate Analysis on Predictive Factors of Malignant Risk for Follicular Thyroid Neoplasms With a Maximum Diameter≤4 cm
10.3969/j.issn.1009-6604.2025.03.001
- VernacularTitle:最大径≤4 cm甲状腺滤泡性肿瘤恶性风险预测因素的多因素分析
- Author:
Xin LI
1
;
Xiangyun YAO
;
Fang MEI
;
Bo YU
;
Jiuping HUANG
;
Shibing SONG
Author Information
1. 北京大学第三医院普通外科,北京 100191
- Publication Type:Journal Article
- Keywords:
Follicular thyroid neoplasms;
Ultrasonography;
Follicular thyroid carcinoma;
Follicular thyroid adenoma;
Predictive factors
- From:
Chinese Journal of Minimally Invasive Surgery
2025;25(3):129-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate predictive factors of malignant risk for follicular thyroid neoplasms(FTN)with a maximum diameter≤4 cm,providing evidence for preoperative diagnosis and individualized treatment for FTN patients.Methods We retrospectively analyzed clinical data of FTN patients with a maximum tumor diameter≤4 cm treated at our hospital between January 2018 and December 2023.Based on postoperative pathological diagnosis,the patients were divided into follicular thyroid carcinoma(FTC)group and follicular thyroid adenoma(FTA)group.Univariate and multivariate logistic regression analyses were performed to explore predictive factors of malignant risk of FTN.Results A total of 870 patients were included,comprising of 745 patients(85.6%)in the FTA group and125 patients(14.4%)in the FTC group.The univariate analysis showed thatage,gender,BMI,comorbidity of Hashimoto's thyroiditis,number and location of nodules,the maximum diameter of nodules,internal structure of nodules,and internal blood flow signals had no significant differences(P>0.05),while nodule echogenicity,margins,halo,taller-than-wide shape,and calcification had significant differences(P<0.05).Multivariate logistic regression analysis revealed that irregular margins(OR=3.061,95%CI:1.653-5.667,P=0.000),uneven thickness of the halo(OR=5.868,95%CI:1.258-27.377,P=0.024),and peripheral rim calcification(OR=4.364,95%CI:1.329-14.333,P=0.015)were predictive factors of malignant risk for FTC.Conclusions Ultrasound features have certain value for evaluating benign or malignant nature of FTN.Careful assessment of nodule margins,halo,and calcification can facilitate early diagnosis and treatment of small FTN.
