Research Progress on Regulation of Tumor-Associated Macrophages Polarization by Intratumoral Microorganisms in Pancreatic Cancer
10.3971/j.issn.1000-8578.2025.24.1246
- VernacularTitle:胰腺癌瘤内微生物调控肿瘤相关巨噬细胞极化的研究进展
- Author:
Yaxian YAN
1
;
Wei WANG
Author Information
1. 430065 武汉,武汉科技大学医学部医学院;441000 襄阳,湖北文理学院附属襄阳市中心医院消化内科
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Intratumoral microorganisms;
Tumor-associated macrophages;
Tumor micro-environment
- From:
Cancer Research on Prevention and Treatment
2025;52(3):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have revealed the presence of specific microorganisms in pancreatic cancer.Accumulating evidence suggests a correlation between changes in the microbiome and tumor immune function in pancreatic cancer.Various stimuli within the tumor microenvironment(TME)prompt the polarization of tumor-associated macrophages(TAMs)toward the immune-activating M1 phenotype or immunosuppressive M2 phenotype.Microorganisms in the TME can facilitate or inhibit tumor growth,metastasis,drug resistance,and other processes by influencing the phenotypes and functions of macrophages.This article reviews the mechanisms by which anaerobic bacteria regulate TAM polarization in the TME of pancreatic cancer.Additionally,it discusses the effects of bacterial components and metabolites on TAM polarization,aiming to provide new targets for the diagnosis and treatment of pancreatic cancer from a microbial perspective.
