Study of the optimal concentration of anlotinib for ovarian clear cell carcinoma cells
10.3969/j.issn.1673-9701.2025.21.009
- VernacularTitle:安罗替尼对卵巢透明细胞癌最适浓度探讨
- Author:
Tianyu ZHU
1
;
Shuxuan LI
;
Yuxuan MA
;
Yi TANG
;
Yongjing ZHOU
Author Information
1. 江苏大学医学院,江苏镇江 212013
- Publication Type:Journal Article
- Keywords:
Anlotinib;
Ovarian clear cell carcinoma;
Mechanism of action;
Optimal concentration
- From:
China Modern Doctor
2025;63(21):37-40,123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism and optimal concentration of anrotinib on ovarian clear cell carcinoma.Methods Ovarian clear cell carcinoma cells were cultured in vitro,by using renal clear cell carcinoma cells and renal papillary cell carcinoma cells as control cancer cells,and the effects of different concentrations of anlotinib(5,10,15,20μmol/L)on the proliferation,migration,and invasion capabilities of three cancer cell lines were investigated.Compared with the experimental results of renal clear cell carcinoma cells and renal papillary cell carcinoma cells,the advantages of anlotinib on ovarian clear cell carcinoma cells were investigated and advanced its position in clinical practice.Results Anlotinib at the concentrations of 5,10,15,and 20μmol/L can effectively inhibit the proliferation,migration,and invasion ability of ovarian clear cell carcinoma cells,renal clear cell carcinoma cells,and renal papillary cell carcinoma cells.Among them,the optimal action concentration of anlotinib on all three cancer cells fell in the range of 5-10 μmol/L.However,in the three cancer cells,anlotinib was more potent in ovarian clear cell carcinoma cells.Conclusion The effect of anlotinib on ovarian clear cell carcinoma cells has obvious advantages over renal clear cell carcinoma cells and renal papillary cell carcinoma cells,with the optimal concentration of 5-10 μmol/L.
