Discussion on the Role of Mitophagy in Ulcerative Colitis from the Theory of"Spleen Acting as the Defense for Host"
10.19879/j.cnki.1005-5304.202410043
- VernacularTitle:从"脾为之卫"理论探析线粒体自噬在溃疡性结肠炎中的作用
- Author:
Dan LONG
1
;
Wei ZHANG
;
Yin XU
;
Ying ZHU
Author Information
1. 湖南中医药大学第一附属医院,湖南 长沙 410007;湖南中医药大学,湖南 长沙 410208
- Publication Type:Journal Article
- Keywords:
spleen acting as the defense for host;
mitophagy;
ulcerative colitis;
TCM;
immunity
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(8):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is an immune-mediated inflammatory disease of the intestine.Mitochondrial homeostatic imbalance plays an important role in the development of UC.Spleen-stomach qi deficiency is the root cause of UC.This article focused on the theory of"spleen acting as the defense for host"and mitophagy to explain the pathological mechanism of UC,and discussed the correlation between mitochondria and spleen in combination with the related research of traditional Chinese and Western medicine.It proposed that mitophagy disorder is the microscopic manifestation of UC"spleen losing the defense",explored the application of the method of strengthening the spleen and restoring defense at the micro level to improve mitochondrial function,alleviate intestinal inflammation,and provide reference for theoretical research and clinical prevention and treatment of UC.
