Correlation Study between TCM Susceptibility of Pulmonary Nodules and Methylation of SHOX2/RASSF1A/PTGER4 Genes
10.19879/j.cnki.1005-5304.202502563
- VernacularTitle:肺小结节中医易患体质与SHOX2/RASSF1A/PTGER4基因甲基化的相关性研究
- Author:
Renshuang CAO
1
;
Bin WANG
1
;
Xue LAI
1
;
Shan LI
1
;
Feng GAO
1
Author Information
1. 中国中医科学院望京医院,北京 100102
- Publication Type:Journal Article
- Keywords:
pulmonary nodules;
SHOX2/RASSF1A/PTGER4 gene methylation level;
TCM susceptibility;
independent risk factor analysis;
prospective cross-sectional study
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(8):146-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors associated with the risk of positive methylation levels of SHOX2/RASSF1A/PTGER4 genes in patients with pulmonary nodules with TCM susceptibility.Methods Using a cross-sectional study method,totally 165 patients with pulmonary nodules from the Respiratory Department of Wangjing Hospital,China Academy of Chinese Medical Sciences were included from May 2024 to December 2024.Clinical data such as patients'general medical history,nodule imaging reports,lung cancer gene methylation levels,and TCM constitution assessments were organized and statistically analyzed.On the basis of exploring the correlation between various variables and the risk of positive methylation of lung cancer genes through univariate correlation analysis,a binary logistic regression model was used for independent risk factor analysis.Results Univariate correlation analysis showed that age,gender,TCM susceptibility score,diameter of pulmonary nodules and upper lobe of the right lung were correlated with positive methylation levels of the SHOX2/RASSF1A/PTGER4 genes(P=0.03,P=0.02,P=0.01,P<0.01,P=0.03);and binary Logistic regression analysis showed that yang-deficiency quality,qi deficiency,qi depression and phlegm-dampness,the four pulmonary nodules susceptibility body scores were significantly and positively correlated with the risk of SHOX2/RASSF1A/PTGER4 gene methylation positivity.Compared with yang deficiency,phlegm-dampness and qi depression had a higher risk of gene methylation positivity for patients with pulmonary nodules(P=0.04,P=0.02).Conclusion Older age,males,and TCM susceptibility body correlated with the lung cancer gene methylation positive risk are correlated,in which phlegm dampness and qi depression are independent risk factors.
