Predictive value of combined detection of two serum markers for poor prognosis in patients with ACI after endovascular intervention
10.3969/j.issn.1009-0126.2025.08.016
- VernacularTitle:两种血清标志物联合检测对血管内介入治疗急性脑梗死患者预后不良的预测价值分析
- Author:
Zhongmin ZHANG
1
;
Xiaoli WANG
1
;
Huanyi WANG
1
;
Jian HAN
1
;
Yang JIAO
1
Author Information
1. 157011 牡丹江医科大学附属红旗医院神经内三科
- Publication Type:Journal Article
- Keywords:
angiopoietin-like 4 protein;
chemokine CCL1;
brain infarction;
prognosis;
forecasting
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(8):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum angiopoietin-like protein 4(ANGPTL4)and C-X3-C motif chemokine ligand 1(CX3CL1)for poor prognosis in patients with acute cerebral infarction(ACI)undergoing intravascular intervention therapy.Methods A total of 180 ACI patients undergoing endovascular intervention in our department from January 2021 to February 2024 were prospectively recruited and served as the study group,and according to the prognosis,they were divided into a good prognosis group(97 cases)and a poor prognosis group(83 cases).Another 180 individuals who taking healthy checkup in the same period served as the control group.The levels of ANGPTL4 and CX3CL1 were measured by ELISA.Results The ser-um ANGPTL4 level was significantly lower while that of CX3CL1 was obviously higher in the study group than the control group(P＜0.01).The poor prognosis group had notably longer time from onset to admission and larger proportions of having NIHSS score at admission≥15 and an-terior circulation cerebral infarction,lower serum ANGPTL4 level and higher CX3CL1 level when compared with the good prognosis group(P＜0.01).Multivariate logistic regression analysis showed that time from onset to admission,NIHSS score at admission,location of cerebral infarc-tion,and CX3CL1 were risk factors,and ANGPTL4 was a protective factor for poor prognosis in ACI patients(P＜0.05,P＜0.01).ROC curve analysis showed that the AUC value of serum ANGPTL4,CX3CL1 and their combinzation in predicting poor prognosis in ACI patients was 0.816(95％CI:0.755-0.877),0.860(95％CI:0.791-0.930),and 0.901(95％CI:0.846-0.956),respectively,and the combined indicators showed better predictive value than each indicator alone(Z=2.716,Z=2.732,P＜0.05).Conclusion Serum ANGPTL4 and CX3CL1 levels are abnormal-ly expressed in ACI patients after intravascular intervention therapy,and are related to prognosis.Their combined detection can improve the predictive value for poor prognosis.
