Research Progress on Targeting Autophagy in Pan-creatic Cancer Treatment
10.11735/j.issn.1004-0242.2025.08.A007
- VernacularTitle:靶向自噬在胰腺癌治疗中的研究进展
- Author:
Dongfeng SONG
1
;
Tingting YOU
1
;
Hui TANG
1
;
Jinrong YING
1
;
Zhao SUN
1
;
Chunmei BAI
1
Author Information
1. 北京协和医院,中国医学科学院北京协和医学院,北京 100730
- Publication Type:Journal Article
- Keywords:
autophagy;
pancreatic cancer;
chemotherapy;
targeted therapy;
immunotherapy
- From:
China Cancer
2025;34(8):653-659
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a cellular self-degradation process that maintains homeostasis and has been shown to promote tumor progression in advanced stages.Pancreatic cancer cells and the surrounding stromal cells exhibit high levels of autophagy.Therefore,targeting au-tophagy has emerged as a promising therapeutic strategy for pancreatic cancer.This review focuses on research targeting autophagy in pancreatic cancer treatment,elaborating on the roles and underlying mechanisms of autophagy in pancreatic cancer cell proliferation,metas-tasis,modulation of the tumor immune microenvironment,and drug resistance.Additional-ly,we summarize preclinical and clinical studies investigating autophagy-targeted therapies both as monotherapy and in combination with other treatments,aiming to provide new theo-retical rationale and therapeutic strategies for pancreatic cancer management.
