Correlation between vascular senescence indicators and total burden score of MRI in patients with cerebral small vascular disease
10.3969/j.issn.1009-0126.2025.08.020
- VernacularTitle:脑小血管病患者血管衰老指标与磁共振成像总负荷评分的相关性
- Author:
Xiaoyu CUI
1
;
Ying FAN
1
;
Haibo LI
1
;
Linying MA
1
;
Bin LIU
1
;
Xiaokun WU
1
;
Wenjing MAO
1
;
Jinxia ZHANG
1
Author Information
1. 063000 唐山,华北理工大学附属医院神经内一科
- Publication Type:Journal Article
- Keywords:
cerebral small vessel diseases;
magnetic resonance imaging;
cardio ankle vascular index;
ankle brachial index
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(8):1071-1075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of vascular senescence indicators,brachial-ankle pulse wave velocity(baPWV),cardio-ankle vascular index(CAVI),ankle-brachial index(ABI)with total burden of MRI in patients with cerebral small vessel disease(CSVD).Methods A total of 200 CSVD patients admitted to our hospital from November 2023 to October 2024 were retrospectively recruited,and based on their total MRI burden,they were divided into a low-burden group(score:0-1,103 cases)and a high-burden group(score:2-4,97 cases).A athero-sclerosis monitoring device(VS-1500A)was used to detect baPWV,CAVI,and ABI values.The relationships of the three indicators with total MRI burden score and their predictive values for the burden score were analyzed.Results The high-burden group had significantly higher BMI,el-evated homocysteine and uric acid levels,and increased baPWV and CAVI,but lower ABI than the low-burden group(P＜0.01).Multivariate logistic analysis showed that baPWV,CAVI and ABI were independent influencing factors for high MRI burden of CSVD patients.Spearman correlation analysis showed that baPWV and CAVI values were positively correlated(r=0.589,P=0.000;r=0.458,P=0.000),and ABI was negatively correlated with the total MRI burden score of CSVD patients(r=-0.352,P=0.000).ROC curve analysis showed that baPWV(AUC=0.816,P=0.000),CAVI(AUC=0.725,P=0.000)and ABI(AUC=0.676,P=0.000)were all predic-tors for high MRI burden score in CSVD patients.Conclusion baPWV and CAVI are positively,and ABI is negatively correlated with the total MRI burden score of CSVD patients.baPWV,CAVI and ABI show higher predictive value for the high burden score,with baPWV most significant.
