Effect of miR-185-5p expression on myocardial metabolic abnormalities mediated by inflammatory response in patients with CHF
10.3969/j.issn.1009-0126.2025.08.011
- VernacularTitle:微小RNA-185-5p表达对慢性心力衰竭患者炎性反应介导的心肌代谢异常的影响
- Author:
Ling LI
1
;
Haichao FAN
1
;
Junhong LIU
1
Author Information
1. 056200 邯郸,华北医疗健康集团峰峰总医院心血管一科
- Publication Type:Journal Article
- Keywords:
microRNAs;
heart failure;
energy metabolism;
interleukin-6;
C-reactive protein
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(8):1026-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of miR-185-5p expression changes in inducing myo-cardial metabolic abnormalities mediated by inflammatory responses in patients with chronic heart failure(CHF).Methods A total of 228 CHF patients treated in our department from June 2022 to June 2024 were prospectively enrolled and served as observation group,and another 108 healthy individuals taking physical examinations were subjected as the control group.Cardioechography was used to detect ejection time,fractional shortening,stroke volume,left ventricular mass index(LVMI),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and left ventricular end-systolic diameter(LVESD).Then LV circumferential end-systolic wall stress(CESS)and MEE were calculated.The levels of IL-6,CRP,and TNF-α were detected with ELISA.Results The expression of miR-185-5p was significantly lower,and the levels of IL-6,CRP,and TNF-α were obviously higher in the observation group than the control group(P＜0.01).MiR-185-5p was negatively correlated with IL-6,CRP and TNF-α levels(r=-0.765,-0.558,-0.693,P＜0.01);MEE was negatively correlated with miR-185-5p(r=-0.594,P＜0.01)and positively with IL-6,CRP and TNF-α levels(r=0.712,0.684,0.559,P＜0.01).Multivariate logistic regression analysis showed that ejection time,fractional shortening,stroke volume,LVEF,and miR-185-5p were independent protective factors for MEE,while LVMI,LVESD,LVEDD,CESS,IL-6,CRP,and TNF-α were independent risk factors for MEE(P＜0.05,P＜0.01).Conclusion Low expression of miR-185-5p is associated with myocardial metabolic abnormalities mediated by inflammatory responses in CHF patients.
