Clinical study on P-glycoprotein and T lymphocyte subsets in children with ITP
10.3969/j.issn.1673-9701.2025.19.004
- VernacularTitle:P-糖蛋白及T淋巴细胞亚群与儿童ITP的临床研究
- Author:
Bihan ZHANG
1
;
Jianying NING
1
Author Information
1. 石河子大学第一附属医院儿科,新疆石河子 832008
- Publication Type:Journal Article
- Keywords:
Primary immune thrombocytopenia;
P-glycoprotein;
T lymphocyte subsets;
Glucocorticoid
- From:
China Modern Doctor
2025;63(19):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between the expression of P-glycoprotein(P-gp)and T lymphocyte subsets with clinical efficacy in children with primary immune thrombocytopenia(ITP).Methods A total of 120 children diagnosed with ITP in the First Affiliated Hospital of Shihezi University from June 2022 to June 2024 were selected as research subjects.The clinical data,T lymphocyte subsets and P-gp test results were collected.According to differences in treatment plans and therapeutic effects,they were divided into glucocorticoid(GC)treatment group(GC-effective group,GC-ineffective group)and intravenous immunoglobulin(IVIg)treatment group(IVIg-effective group,IVIg-ineffective group).The levels of P-gp and T lymphocyte subsets were compared within each group.Results P-gp was positively correlated with CD8+and negatively correlated with CD4+/CD8+(P＜0.05).The P-gp and CD8+of children in GC-effective group were significantly lower than those in GC-ineffective group,and CD4+/CD8+ratio was significantly higher than that in GC-ineffective group(P＜0.05).However,there was no statistically significant difference in CD4+between two groups of children(P＞0.05).There were no statistically significant differences in P-gp,CD4+,CD8+and CD4+/CD8+between IVIg-effective group and IVIg-ineffective group(P＞0.05).Conclusion The expression levels of P-gp and T lymphocyte subsets are associated in children with ITP.High expression levels of P-gp and CD8+suggest that GC therapy may be ineffective.Monitoring the level of P-gp and T lymphocyte subsets may help predict GC treatment responsiveness in pediatric ITP patients.
