Clinical Application of Ischemia-free Liver Transplantation
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0406
- VernacularTitle:无缺血肝移植技术的临床应用
- Author:
Mingqiang ZHU
1
;
Xiaohua WANG
1
Author Information
1. 赣南医科大学第一附属医院肝胆外科,江西 赣州 341000
- Publication Type:Journal Article
- Keywords:
liver transplantation;
ischemia-reperfusion injury;
ischemia-free;
selection of donor and recipient;
marginal donor liver;
postoperative complications
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(4):598-606
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation remains the optimal clinical treatment for patients with terminal liver diseases.Decades of persistent efforts from experts worldwide have propelled continuous innovation and advancement in this field.Chinese liver transplantation teams have achieved significant progress in the clinical liver transplantation.As organ transplantation enters its Era 2.0,ischemia-free organ transplantation has been expanded beyond the liver to include heart,lung,kidney and other transplantations,demonstrating broad application potential.Ischemia-free liver transplantation(ILFT)mitigates cell damage and postoperative complications associated with ischemia-reperfusion injury by maintaining continuous blood perfusion of the donor liver throughout procurement,preservation,and transplantation.This innovation also expands the utilization of marginal donor livers(e.g.,those from aged donors or with adipose infiltration),thereby alleviating donor shortage.Despite these advantages,ILFT faces challenges,including technical complexity,high equipment costs,and the absence of large-scale,multicenter long-term follow-up data.More effort should be put into optimizing portable perfusion systems,establishing standardized protocols,and investigating the synergistic potential of ILFT with immunomodulatory therapies.As the ILFT technology matures,it will improve liver transplantation outcomes,expand the donor pool,and enhance recipients'quality of life.This review presents the development of ILFT,criteria for donor and recipient selection,surgical techniques,and postoperative complications to lay a foundation for its broader clinical application.
