Effect observation of Callicarpa nudiflora combined with dexamethasone retention enema in the treatment of acute radiation proctitis
10.3781/j.issn.1000-7431.2025.2403-0173
- VernacularTitle:裸花紫珠联合地塞米松保留灌肠治疗急性放射性直肠损伤的疗效观察
- Author:
Li LIU
1
;
Weirong YAO
;
Xiaoli WANG
;
Huaigen ZHANG
Author Information
1. 江西省人民医院(南昌医学院第一附属医院)肿瘤科,江西 南昌 330000
- Publication Type:Journal Article
- Keywords:
Callicarpa nudiflora;
Dexamethasone;
Retention enema;
Acute radiation proctitis
- From:
Tumor
2025;45(1):47-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy differences between the combination therapy of Callicarpa nudiflora and dexamethasone versus dexamethasone monotherapy via retention enema in the treatment of acute radiation proctitis.Methods:A total of 100 patients with pelvic malignancies who developed acute radiation proctitis during radiotherapy at Jiangxi Provincial People's Hospital from November 2021 to June 2023 were enrolled,and randomly divided into two groups:a control group(50 cases)vs a treatment group(50 cases).Based on the acute radiation injury scoring criteria established by the Radiation Therapy Oncology Group(RTOG),patients with injury severity scores≤1 were excluded.Subsequently,the remaining patients received the following interventions:the control group(45 cases)underwent single-agent dexamethasone retention enema,while the treatment group(47 cases)received a combined regimen of Callicarpa nudiflora combined with dexamethasone retention enema.Clinical symptoms,defecation frequency,and routine fecal parameters(leukocyte and erythrocyte counts)were recorded before and at 2 weeks of retention enema,to compare the efficacy differences between the two regimens.Results:A statistically significant difference in therapeutic efficacy was observed between the treatment and control groups(χ2=11.37,P=0.003,P<0.05),with the regimen of Callicarpa nudiflora combined with dexamethasone retention enema in the treatment group demonstrating a markedly higher efficacy rate compared to the regimen of single-agent dexamethasone retention enema in the control group(82.2%vs 62.2%).Conclusion:Callicarpa nudiflora combined with dexamethasone retention enema in the treatment of acute radiation proctitis,can significantly alleviates clinical symptoms and improves life quality of patients with acute radiation proctitis.This approach provides novel insights for optimizing clinical treatment strategies for acute radiation proctitis.
