The mechanism and application prospects of PAK5 in the migration and invasion of malignant tumors
10.3781/j.issn.1000-7431.2025.2403-0166
- VernacularTitle:PAK5在肿瘤细胞迁移与侵袭过程中的作用机制及应用前景
- Author:
Jiamin ZHANG
1
;
Daliu MIN
1
Author Information
1. 上海交通大学医学院附属第六人民医院肿瘤内科,上海 200233
- Publication Type:Journal Article
- Keywords:
p21-activated kinase 5;
Cell migration and invasion;
Epithelial-mesenchymal transition;
MicroRNA;
Cytoskeletal rearrangement
- From:
Tumor
2025;45(1):75-84
- CountryChina
- Language:Chinese
-
Abstract:
p21-activated kinase 5(PAK5),a critical member of the PAK family,plays a significant regulatory role in cellular signaling transduction and cytoskeleton rearrangement.Accumulating researches have revealed that PAK5 is aberrantly expressed in various human malignancies,and its expression level is significantly correlated with tumor metastasis,invasiveness,and clinical prognosis of patients.At the molecular level,PAK5 promotes tumor cells migration and invasion by activating key signaling pathways(such as Wnt/β-catenin and MAPK)to induce epithelial-mesenchymal transition(EMT),modulating tumor-associated microRNA(miRNA)networks,and remodeling actin cytoskeleton to enhance cellular motility.This review systematically dissects the molecular structural features and phosphorylation-dependent activation mechanisms of PAK5,delves into molecular mechanisms of PAK5 in tumor cells migration and invasion,and evaluates the potential of PAK5 as a therapeutic target.This work aims to provide a new perspective for developing PAK5-targeted precision therapeutic strategies in malignant tumors.
