Evidence-based on Mendelian randomization:causal relationship between plasma lipids and different subtypes of lung cancer
10.3781/j.issn.1000-7431.2025.2404-0182
- VernacularTitle:血脂水平与不同亚型肺癌的因果关系:一项孟德尔随机化研究
- Author:
Wei ZHANG
1
;
Jian GAO
1
;
Yi TONG
1
;
Yu GAN
1
Author Information
1. 上海交通大学医学院附属仁济医院上海肿瘤研究所肿瘤系统医学全国重点实验室,上海 200032
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Plasma lipids;
Mendelian randomization;
Genome-Wide Association Study
- From:
Tumor
2025;45(1):22-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To Evaluate the potential causal relationship between the levels of 179 lipids in peripheral blood and the risk of different subtypes of lung cancer by Mendelian randomization analysis.Methods:A two-sample Mendelian randomization analysis was performed using data from the Genome-Wide Association Study(GWAS),and sensitivity analysis was performed to verify the reliability of the results.Single nucleotide polymorphisms(SNPs)were used as instrumental variables,and GWAS data for different subtypes of lung cancer were used as outcome variables.We analyze potential causal associations between the levels of 179 lipids and the risk of different subtypes of lung cancer.Results:The causal relationship between phosphatidylcholine and lung adenocarcinoma was established as a protective factor,and Sphingomyelin and Triacylglycerol have been identified as being linked to lung adenocarcinoma and function as risk factors.Phosphatidylcholine were found to have a causal association with lung squamous cell carcinoma serving as a protective factor,and Phosphatidylethanolamine and Sphingomyelin were identified as risk factors for lung squamous cell carcinoma.However,the effects of different subtypes of Phosphatidylcholine on lung adenocarcinoma and lung squamous cell carcinoma were different.The study did not find evidence that lipids can influence small cell lung carcinoma.Conclusion:This study provides evidence of a causal relationship between lipids level features and different subtypes of lung cancer.
