Exploring the polarization imbalance of macrophages in the process of"inflammation-cancer transformation"of colitis associated cancer based on"spleen corresponding to late summer with aversion to dampness"
10.3969/j.issn.1008-9691.2025.02.019
- VernacularTitle:基于"脾应长夏恶湿"探讨结肠炎相关癌症"炎癌转化"过程中巨噬细胞的极化失衡
- Author:
Xu LIU
1
;
Leilei LIU
;
Yu WU
;
Yu WANG
Author Information
1. 天津医科大学附属南开医院,天津 300102
- Publication Type:Journal Article
- Keywords:
Colitis associated cancer;
Spleen corresponding to late summer;
The spleen dislikes dampness;
Inflammation-cancer transformation;
Colitis
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2025;32(2):223-226
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of colitis associated cancer(CAC)is closely related to the intestinal microenvironment.Traditional Chinese medicine(TCM)posits that"spleen deficiency"is the basic pathogenesis of colon cancer occurrence and development,and plays a key role in the process of"inflammation-cancer transformation".However,at present,the pathogenesis of spleen in the course of its pathogenesis is mostly focused on the body's own system,and few are discussed in combination with the theoretical basis of TCM's holistic view of"correspondence between man and nature".The spleen,as a taiyin organ with a damp-earth nature,relies on yang energy for movement,inherently averses dampness,and governs ascending qi.Late summer is mainly wet,which can easily obstruct the spleen qi,curb the upward trend and stop the spread opportunity when the wettability sticks and has a downward trend.This suggests that the influence of external environmental factors on the body should be comprehensively considered in the study of the classical process of"intestinal flora disturbance-inflammatory microenvironment formation-tumor formation"experienced in the pathogenesis of CAC.Based on the complementarity,mutual penetration and mutual promotion of the theories of traditional Chinese and western medicine,this paper discusses the role of external environmental factors in the occurrence of CAC focused on the mechanism of macrophage polarization imbalance during the formation of tumor inflammatory microenvironment,and provides a basis for the theoretical integration and development of TCM"time-dependent treatment"prevention and treatment strategies.
