Advances in the construction and application of organoid models for lymphoma
10.12354/j.issn.1000-8179.2025.20250515
- VernacularTitle:淋巴瘤类器官的模型构建及应用进展
- Author:
Yang JINGSHI
1
;
Kou YING
Author Information
1. 四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院肿瘤内科(成都市 610041)
- Publication Type:Journal Article
- Keywords:
organoids lymphoma;
immunotherapy;
precision medicine
- From:
Chinese Journal of Clinical Oncology
2025;52(12):643-646
- CountryChina
- Language:Chinese
-
Abstract:
Lymphomas represent a group of highly heterogeneous malignant tumors.The tumor microenvironment(TME)surrounding these tumors plays a crucial role in disease progression and the efficacy of therapeutic interventions.Traditional two-dimensional cell cul-ture models fail to accurately recapitulate the inherent complexity of three-dimensional(3D)in vivo architecture.Organoid technology provides a novel tool for lymphoma research,utilizing 3D culture systems to reconstruct tumor tissue organization and functionality.Despite the potential of this technology,the development of lymphoma organoid models remains a significant challenge.Developing lymphoma or-ganoid models faces numerous hurdles,including replicating the unique biological characteristics of lymphoma and itscomplexmicroenvir-onment.This study provides a systematic summary of challenges associated with lymphoma organoid construction and describes recent ad-vances in relevant methodologies.Moreover,the study further reviews recent advances in co-culture techniques combining lymphoma or-ganoids and immune cells,including protocols for culturing patient-derived primary central nervous system lymphoma organoids and patient-derived lymphoma organoids.These advances have significantly facilitated the clinical translation of lymphoma research,transitioning it from fundamental mechanistic studies toward personalized and precision therapeutic approaches.
