Gut microbiota and advances in immunotherapy for colorectal cancer
10.12354/j.issn.1000-8179.2025.20250279
- VernacularTitle:肠道菌群与结直肠癌免疫治疗的研究进展
- Author:
Wang LI
1
;
Li WEIJIA
1
;
Yang ZIQI
1
;
Mao JIE
1
Author Information
1. 兰州大学第二医院普外科(兰州市 730000)
- Publication Type:Journal Article
- Keywords:
gut microbiota;
colorectal cancer;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2025;52(12):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is one of the most prevalent gastrointestinal tumors;however,its pathogenesis is poorly understood.Therapeutic strategies for CRC vary according to molecular typing.Immune checkpoint inhibitors(ICIs)have shown significant efficacy in pa-tients with mismatch repair-deficient/microsatellite instability-high(dMMR/MSI-H)CRC.However,ICIs are less effective in patients with mis-match repair-proficient/microsatellite instability-low(pMMR/MSI-L).Intestinal flora have been found to enhance immunotherapy for CRC and ameliorate immunotherapy-related adverse effects by modulating immune responses through multiple mechanisms,particularly in pa-tients with pMMR/MSI-L CRC.This article reviews the key role of intestinal flora in regulating immunotherapy for CRC,discusses the pro-gress of related studies,and considers the clinical translational prospects of diet,probiotics,and fecal microbiota transplantation(FMT).
