Advancements in research on the distribution,functionality,and clinical implications of SPP1+macrophages in colorectal cancer
10.12354/j.issn.1000-8179.2025.20250421
- VernacularTitle:结直肠癌中SPP1+巨噬细胞的分布和功能及临床意义研究进展
- Author:
Long YUXIN
1
;
Yang YUE
;
Jin SHUO
;
Zhang HONGMEI
Author Information
1. 陕西中医药大学(陕西省 咸阳市 712046);空军军医大学第一附属医院(西京医院)肿瘤科
- Publication Type:Journal Article
- Keywords:
colorectal cancer(CRC);
tumor microenvironment(TME);
SPP1+macrophages;
osteopontin
- From:
Chinese Journal of Clinical Oncology
2025;52(12):633-637
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is a prevalent malignancy of the digestive tract in China;it exhibits aggressive progression that is closely associated with tumor microenvironment(TME)modulation.Tumor-associated macrophages,which are pivotal immunomodulatory com-ponents of the TME,demonstrate remarkable functional heterogeneity.Among these,secreted phosphoprotein 1-positive tumor-associated macrophages(SPP1+TAMs)represent a distinct subset with well-characterized protumorigenic properties.Evidence indicates that SPP1+TAMs exhibit a unique spatial distribution pattern in CRC tissues,with pronounced enrichment at the invasive tumor front and metastatic niches.Through the secretion of SPP1 and other effector molecules,this subset orchestrates multifaceted oncogenic processes,including tumor cell adhesion,migration,angiogenesis,and metastatic dissemination.This review systematically elucidates the spatial distribution,molecular reg-ulatory mechanisms,and clinical implications of SPP1+TAMs in CRC,thereby providing a theoretical foundation for developingnovel diagnost-ic biomarkers and targeted therapeutic strategies.
