Nomogram of ultrasound combined with laboratory indexes for predicting axillary lymph node metastasis of cT1N0 stage breast invasive ductal carcinoma
10.13929/j.issn.1003-3289.2025.04.022
- VernacularTitle:超声联合实验室指标列线图预测cT1N0期乳腺浸润性导管癌腋窝淋巴结转移
- Author:
Guifang CHEN
1
;
Qing ZHANG
1
;
Pengfei ZHU
1
;
Yuxiang MAO
1
;
Jue WANG
1
;
Qiuyi CHEN
1
;
Ying HE
1
Author Information
1. 南通市肿瘤医院超声科,江苏 南通 226361
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
lymphatic metastasis;
ultrasonography;
nomograms
- From:
Chinese Journal of Medical Imaging Technology
2025;41(4):611-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of nomogram of ultrasound combined with laboratory indexes for predicting axillary lymph node metastasis(ALNM)of stage cT1N0 breast invasive ductal carcinoma(IDC).Methods A total of 77 cases with pathologically diagnosed stage cT1N0 single breast IDC were retrospectively collected,including 23 cases with and 54 cases without ALNM.Univariate and multivariate binary logistic regression analysis were used to analyze clinical data,laboratory indicators and ultrasonic manifestations,then the independent predictors of ALNM of stage cT1N0 breast IDC were screened to establish laboratory indexes model,ultrasound model and combined model,respectively,and nomogram of the combined model was drawn.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive efficacy of each model.The consistency of results of combined model and actual results was analyzed using calibration curve.Decision curve analysis(DCA)was used to explore the clinical value of each model.Results Serum carbohydrate antigen 153(CA153)(OR=1.132),platelet-to-lymphocyte ratio(PLR)(OR=1.020)and echo attenuation behind the lesion on ultrasound(OR=8.789)were all independent predictors of ALNM in stage cT1N0 breast IDC(all P＜0.05),and the area under the curve(AUC)of laboratory indexes model,ultrasound model and combined model for predicting ALNM of stage cT1N0 breast IDC was 0.757,0.616 and 0.836,respectively.The consistency of the predicted results of combined model and actual results was good.When the threshold was higher than 0.15,the net benefit of combined model was higher than that of the other 2 models.Conclusion Nomogram of ultrasound combined with laboratory indexes could effectively predict ALNM of stage cT1N0 breast IDC.
