Mechanism of abnormal metastable dynamics in Alzheimer disease based on brain network dynamic model
10.13929/j.issn.1003-3289.2025.04.030
- VernacularTitle:基于脑网络动力学模型分析阿尔茨海默病异常亚稳态动力学机制
- Author:
Jing WEI
1
;
Xiaoyang LI
;
Hao GUO
;
Jiayue XUE
;
Yanli YANG
Author Information
1. 山西财经大学信息学院,山西 太原 030006
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
magnetic resonance imaging;
virtual lesioning;
brain network dynamic
- From:
Chinese Journal of Medical Imaging Technology
2025;41(4):651-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of abnormal metastable dynamics in Alzheimer disease(AD)using brain network dynamic model based on MRI.Methods Data of MR T1WI diffusion tensor imaging(DTI)and resting-state functional MRI(rs-fMRI)of 25 AD patients(AD group)38 mild cognitive impairment(MCI)patients(MCI group)and 37 healthy controls(HC group)in AD Neuroimaging Initiative(ADNI)database were collected.Based on abnormal brain structural connectivity and cortical atrophy characteristics of AD group the structural virtual injury brain network model was constructed and the mechanism of abnormal metastable dynamics in AD was explored.Results The abnormal functional connectivity of white matter in AD group was concentrated in visual network(VIS)default mode network(DMN)frontoparietal network(FPN)and limbic network(LIM).The overall metastable state of AD group in sensorimotor network(SMN)dorsal attention network(DAN)&ventral attention network(VAN)(i.e.attention network[AN])and DMN specific perturbation models were all significantly lower than that in HC group and MCI group respectively(all P＜0.001).In AD group local circuits abnormality could be seen in posterior right superior temporal gyrus precentral gyrus caudal anterior cingulate gyrus and isthmus of the cingulate gyrus leading to decrease in global metastability.The structural connection damage of DMN and AN as well as cortical atrophy of FPN had significant impact on metastable dynamics in AD patients.Conclusion Multimodal MRI brain network dynamic model revealed the core factors of mechanism of metastable dynamic decline in AD included DMN AN and FPN abnormalities.
