Correlations of lumbar bone mineral density with serum uric acid,hepatic fat and abdominal fat based on quantitative CT
10.13929/j.issn.1003-3289.2025.04.027
- VernacularTitle:基于定量CT分析腰椎骨密度与血尿酸、肝脏脂肪及腹部脂肪的相关性
- Author:
Yalin WU
1
;
Bibiao DING
;
Hong ZHANG
;
Yusheng YU
;
Dinghu XU
;
Xiaoguang CHENG
Author Information
1. 南京市江宁医院医学影像科,江苏南京 211199
- Publication Type:Journal Article
- Keywords:
bone density;
abdominal fat;
fatty liver;
hyperuricemia;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2025;41(4):637-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations of lumbar bone mineral density(BMD)with serum uric acid(SUA),hepatic fat and abdominal fat based on quantitative CT(QCT).Methods A total of 522 subjects who underwent lumbar QCT were retrospectively enrolled.Subjects with different genders were divided into hyperuricemia(HUA)group and normal SUA group according to SUA levels,and QCT parameters were compared between groups.Meanwhile,subjects with different genders were also divided into normal bone mass group(normal group),osteopenia group and osteoporosis(OP)group,and SUA and QCT parameters were compared among groups.Pearson correlation analyses were performed to explore the correlations of lumbar BMD with age,SUA,visceral adipose tissue(VAT),subcutaneous adipose tissue(SAT)and liver fat content.Results There were 325 males,with 105 ones in HUA group and 220 ones in normal SUA group.There were 197 females,with 26 ones in HUA group and 171 ones in normal SUA group.VAT,SAT and percentage of liver fat content in HUA group of different genders were all higher than those in normal SUA group(all P＜0.05).Among 325 males,there were 196 ones in normal group,105 ones in osteopenia group and 24 ones in OP group among males,and VAT increased successively in the above groups(all P＜0.05).Among 197 females,there were 147 ones in normal group,30 ones in osteopenia group and 20 ones in OP group,and VAT and SAT increased successively in the above groups(all P＜0.05).Lumbar BMD was moderately and weakly negatively correlated with age and VAT in males(r=-0.618,-0.286,both P＜0.001),which was moderately,lowly and weakly negatively correlated with age,VAT and SAT in females,respectively(r=-0.772,-0.451,-0.273,all P＜0.001).Conclusion Increased SUA levels resulted in increased abdominal and liver fat content,and the latter was negatively correlated with lumbar BMD.
