Pulmonary perfusion SPECT/CT imaging for diagnosing pulmonary embolism and combining with clinical and laboratory indicators for predicting prognosis
10.13929/j.issn.1003-3289.2025.04.021
- VernacularTitle:肺灌注SPECT/CT显像诊断肺栓塞并联合临床及实验室指标预测预后
- Author:
Xiaoyu LI
1
;
Jiaxin CAO
1
;
Zhilin ZHANG
1
;
Siyu NIU
1
;
Haiyan LIU
1
Author Information
1. 山西医科大学第一医院核医学科,山西 太原 030001;分子影像精准诊疗省部共建协同创新中心,山西 太原 030001
- Publication Type:Journal Article
- Keywords:
pulmonary embolism;
prognosis;
hematologic tests;
single photon emission computed tomography computed tomography
- From:
Chinese Journal of Medical Imaging Technology
2025;41(4):606-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of pulmonary perfusion SPECT/CT imaging for diagnosing pulmonary embolism(PE)and combining with clinical and laboratory indicators for predicting prognosis.Methods Totally 260 patients with suspected PE were retrospectively collected,and PE was clinically confirmed in 237 cases.The diagnostic efficacy of pulmonary perfusion SPECT/CT imaging and CT pulmonary angiography(CTPA)were compared.Among 237 patients with clinically confirmed PE,160 cases were initially diagnosed who underwent standard anticoagulant therapy and were regularly followed up to 3 months after discharge,and their prognosis were analyzed.Logistic regression was used to analyze clinical data,laboratory indicators and pulmonary perfusion defect scores based on pulmonary perfusion SPECT/CT imaging to screen the independent predictors of poor prognosis of PE of the above patients,and a prediction model was then constructed.Receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to evaluate the predictive efficacy of this model for predicting prognosis of PE.Results The positive rate of PE diagnosed with pulmonary perfusion SPECT/CT was higher than that with CTPA(66.54％[173/260]vs.59.62％[155/260],x2=4.765,P=0.038).Among 160 cases of clinically confirmed PE,poor prognosis was observed in 51 cases,while good prognosis was noticed in 109 cases.Patients' age,blood urea nitrogen,serum creatinine,uric acid,D-dimer level and pulmonary perfusion defect score were all independent predictors for poor prognosis of PE(all P＜0.05),and AUC of the established combined model was 0.731.Conclusion Pulmonary perfusion SPECT/CT imaging could be used for diagnosing PE,and combining with clinical and laboratory indicators could effectively predict prognosis of PE.
