Analysis of influencing factors on outcomes of LSIL patients undergoing cervical biopsy
10.3969/j.issn.1673-9701.2025.13.010
- VernacularTitle:宫颈活检LSIL患者转归的影响因素分析
- Author:
Huiping LU
1
;
Yanyu SHI
1
;
Han WANG
1
;
Yidi YAN
1
;
Junyi ZHOU
1
;
Shujun ZHAO
1
Author Information
1. 郑州大学第三附属医院妇瘤科,河南郑州 450052
- Publication Type:Journal Article
- Keywords:
Low-grade squamous intraepithelial lesion;
Human papilloma virus;
Prognosis;
Risk factor
- From:
China Modern Doctor
2025;63(13):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the factors influencing the natural outcome of low-grade squamous intraepithelial lesions(LSIL)of the cervix.Methods A total of 154 patients who underwent colposcopic cervical biopsy in the Third Affiliated Hospital of Zhengzhou University from January 2022 to January 2023 were selected and divided into negative conversion group(55 cases),continuous group(70 cases)and upgraded group(29 cases)according to the follow-up results.Logistic regression was used to analyze the influence of related factors on the outcome of LSIL.Results There were statistically significant differences in the number of vaginal births,the results of thin-prep cytology test,human papilloma virus(HPV)typing,whether vaginal LSIL was combined,whether there were symptoms,and vaginal microecology among three groups(P＜0.05).Multivariate Logistic analysis showed that combined vaginal LSIL,vaginal microecological abnormalities,atypical squamous cell-cannot exclude high-grade squamous intraepithelial lesion(ASC-H)/high-grade squamous intraepithelial lesion(HSIL),HPV 16/18 positive or mixed positive were independent risk factors for persistent infection(P＜0.05),combined vaginal LSIL,symptomatic,vaginal microecological abnormalities,ASC-H/HSIL,HPV 16/18 positive or mixed positive were all independent risk factors for escalation of lesions(P＜0.05).Conclusion Patients with vaginal LSIL,vaginal microecological abnormalities,ASC-H/HSIL,HPV 16/18 positive or mixed positive should be followed up and early intervention to reduce the risk of disease escalation.
