Research Hotspots of PI3K/Akt/mTOR Signaling Pathway in Traditional Chinese Medicine Intervention Mechanism Based on CiteSpace Analysis
10.16466/j.issn1005-5509.2025.04.016
- VernacularTitle:基于CiteSpace探究PI3K/AKT/mTOR信号通路的中医药研究热点
- Author:
Shuaibo ZHU
1
;
Wei JIN
;
Lihong LI
Author Information
1. 浙江中医药大学第二临床医学院 杭州 310053
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
PI3K/AKT/mTOR signaling pathway;
visual analysis;
CiteSpace;
VOS viewer;
bibliometrics;
research progress;
knowledge graph
- From:
Journal of Zhejiang Chinese Medical University
2025;49(4):480-490
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To identify the research hotspots and trends of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling pathway in the traditional Chinese medicine(TCM)intervention mechanism,in order to provide a new research perspective for TCM mechanism exploration and clinical treatment.[Methods]Literatures related to PI3K/AKT/mTOR signaling pathway in the field of traditional Chinese medicine from January 1,2008 to July 5,2024 were searched in the Web of Science core database and CNKI.After screening,CiteSpace 6.1.R6 software was used to draw the cooperation network map of publishing institutions,keyword co-occurrence,clustering,timeline and burst map,and visual analysis was carried out.[Results]A total of 906 articles were included after screening,and the number of articles was on the rise.China had the most countries,with 543 articles.Nanjing University of Chinese Medicine had the most papers,with 28 papers,of which 9 institutions had more than 15 papers.High-frequency keywords included"cancer""neurodegenerative diseases""oxidative stress""apoptosis",and high-intensity burst terms included"network pharmacology""mammalian target""molecular docking".[Conclusion]Regulating the PI3K/AKT/mTOR signaling pathway through Chinese herbal compound and monomer has broad prospects in the treatment of cancer and neurodegenerative diseases.
