Clinical study of sustained-release effect and antibacterial activity of antibiotic bone cement
10.3969/j.issn.1673-9701.2025.11.006
- VernacularTitle:抗生素骨水泥缓释及抑菌活性的临床研究
- Author:
Feng WANG
1
;
Chao ZHANG
;
Lili JIANG
;
Kun DONG
;
Xiuli SUI
Author Information
1. 山东文登整骨烟台医院创伤骨科,山东烟台 264000
- Publication Type:Journal Article
- Keywords:
Antibiotic bone cement;
Orthopedic infections;
Antimicrobial effect
- From:
China Modern Doctor
2025;63(11):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate washing patterns in human simulated body fluids(SBF)by combining high doses of vancomycin,manuperenan and single compound with bone cement.The antibacterial effect of five common bacteria in orthopaedic infections were observed.Methods Vancomycin 2g and meropenem 3g were combined or alone mixed with ordinary bone cement 20g in aseptic operation.Six copies of antibiotic bone cement pellets were made,immersed in SBF,replaced with SBF buffer every 48 hours,sampled every 24 hours 2 μl drops in methicillin-resistant staphylococcus aureus(MRSA),petries of staphylococcus aureus,pseudomonas aeruginosa,E.coli,and extended-spectrum beta-lactamase(ESBL)-positive E.coli were observed for 24 hours and measured the size of the bactericidal rings of the washing fluid at each time point.The antibacterial effect of different ratios of antibiotic bone cement on 5 common orthopedic infections were compared.Results Compound antibiotic group had a better bactericidal effect,and the drug continues to be given for about 30 days.Wancomycin alone could not cover E.coli,ESBL positive E.coli,pseudomonas aeruginosa,and melopicillin alone had only a partial mild bactericidal effect on MRSA around 3 to 6 days after use.The effect on staphylococcus aureus and pseudomonas aeruginosa lasted only about 15 days.Conclusion The combined antibiotic bone cement has a more comprehensive,longer duration and better bactericidal effect than the alone antibiotic bone cement.
