Correlation between the Severity of Chronic Idiopathic Tinnitus and Changes in Stool Properties Based on the Gut-Brain Axis Theory
10.16466/j.issn1005-5509.2025.04.012
- VernacularTitle:基于肠脑轴理论探讨慢性特发性耳鸣严重程度与大便性状改变的相关性
- Author:
Jingxin ZHU
1
;
Rui MA
;
Zekun CHAI
Author Information
1. 北京中医药大学第二临床医学院 北京 100078
- Publication Type:Journal Article
- Keywords:
tinnitus;
severity;
stool character;
gut-brain axis;
spleen and stomach;
diarrhea;
constipation;
pathogenesis
- From:
Journal of Zhejiang Chinese Medical University
2025;49(4):460-465
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the correlation between the severity of chronic idiopathic tinnitus and changes in stool characteristics,and provide valuable epidemiological data for the diagnosis and treatment of chronic idiopathic tinnitus.[Methods]From July 2022 to July 2023,362 patients diagnosed as chronic idiopathic tinnitus were treated in the first Department of Encephalopathy of Dongfang Hospital of Beijing University of Chinese Medicine with tinnitus as the first complaints.All patients were filled in tinnitus handicap inventory(THI)and tinnitus history collection table(gender,age,tinnitus duration,Bristol stool classification).THI severity was grouped as the dependent variable,and the factors above were taken as independent variables.Ordered logistic regression was used for analysis.[Results]The 362 patients with tinnitus included 213(58.84％)having changes in stool properties.Among them,118 cases(32.60％)were of diarrhea,37 cases(10.22％)constipation and 58 cases(16.02％)others.Ordered logistic regression analysis showed that the severity of chronic idiopathic tinnitus was positively correlated with diarrhea[odd ratio(OR)=3.000,P＜0.001]and constipation(OR=2.689,P=0.003),and negatively correlated with the other stool characteristics(OR=0.571,P=0.047).[Conclusion]Diarrhea and constipation may be important factors in exacerbating chronic idiopathic tinnitus and should be emphasized in the clinical management of patients with chronic idiopathic tinnitus.
