Exploration on the Medication Law of Zheng Qizhong in Treating Pediatric Henoch-Sch?nlein Purpura Based on Data Mining
10.19879/j.cnki.1005-5304.202408373
- VernacularTitle:基于数据挖掘探析郑启仲治疗儿童过敏性紫癜用药规律
- Author:
Ruifang YANG
1
;
Pan ZHENG
1
Author Information
1. 河南中医药大学中医学院,河南 郑州 450046
- Publication Type:Journal Article
- Keywords:
Henoch-Sch?nlein purpura;
data mining;
medication law;
experience of famous doctors;
Zheng Qizhong
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(6):52-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the medication law and prescription ideas of Professor Zheng Qizhong in treating pediatric Henoch-Sch?nlein purpura(HSP).Methods Effective outpatient cases of pediatric HSP treated by Professor Zheng Qizhong from January 2018 to December 2023 were selected.The TCM Inheritance Support System 3.5 was utilized,integrating its statistical analysis module and prescription analysis module,to perform quantitative analyses of medication usage frequency,properties-tastes-meridian tropism and therapeutic efficacy.Association rules and clustering analysis were applied to explore latent law in herbal combinations,visualized through network visualization techniques.Combined with interviews,this study further elucidated Professor Zheng Qizhong's fundamental principles and prescription ideas for treating pediatric HSP.Results Totally 280 prescriptions and 189 kinds of Chinese materia medica were screened.The most frequently used herbs included Radix Paeoniae Rubra,Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Astragali Radix and Chuanxiong Rhizoma.The primary properties-tastes were cold,warm,neutral,sweet,bitter and pungent,mainly associated with the liver meridians,spleen meridians,lung meridians and heart meridians.Therapeutic effects focused on heat-clearing,deficiency-tonifying,blood-activating and stasis-resolving,exterior-releasing and hemostasis.Association rule analysis identified 20 medicinal pairs,with the top five high-frequency combinations being Radix Paeoniae Rubra-Angelicae Sinensis Radix,Radix Paeoniae Rubra-Chuanxiong Rhizoma,Angelicae Sinensis Radix-Chuanxiong Rhizoma,Radix Paeoniae Rubra-Glycyrrhizae Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma-Angelicae Sinensis Radix.Clustering analysis yielded four clusters:Cluster I(Glycyrrhizae Radix et Rhizoma,Radix Paeoniae Rubra,Cynanchi Paniculati Radix et Rhizoma Angelicae Sinensis Radix,Gardeniae Fructus,Forsythiae Fructus);Cluster Ⅱ(Angelicae Sinensis Radix,Radix Paeoniae Rubra,Astragali Radix,Chuanxiong Rhizoma,Glycyrrhizae Radix et Rhizoma,Notoginseng Radix et Rhizoma);Cluster Ⅲ(Atractylodis Macrocephalae Rhizoma,Angelicae Sinensis Radix,Poria,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Glycyrrhizae Radix et Rhizoma,Astragali Radix);Cluster Ⅳ(Astragali Radix,Phellodendri Chinensis Cortex,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Glycyrrhizae Radix et Rhizoma,Coptidis Rhizoma,Angelicae Sinensis Radix).Conclusion Professor Zheng Qizhong's treatment for pediatric HSP integrates cold and warm properties,harmonizes the liver and spleen,and adheres to the principle of tonifying qi and activating blood circulation,strengthening the body's healthy qi and eliminating pathogens,emphasizing medicinal pair compatibility and staged treatment based on disease progression.
