Correlation between apathy and imaging markers in patients with arteriosclerotic cerebral small vessel disease
10.3969/j.issn.1009-0126.2025.05.004
- VernacularTitle:小动脉硬化型脑小血管病患者淡漠与影像学标志物的相关性研究
- Author:
Hua LI
1
;
Shangjia MA
;
Dewang GAO
;
Jiayu LÜ
;
Wenlong YU
;
Lu WANG
;
Xia GUO
;
Li'e WU
Author Information
1. 014000 内蒙古科技大学包头医学院
- Publication Type:Journal Article
- Keywords:
cerebral small vessel diseases;
apathy;
stroke,lacunar;
magnetic resonance imaging
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(5):558-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between apathy and imaging markers in pa-tients with aCSVD.Methods A total of 143 patients diagnosed with aCSVD and hospitalized in the Department of Neurology of the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from August 2023 to August 2024 were continu-ously included as the study objects.According to MAES,they were divided into an apathetic group(MAES score＞14,68 cases)and a non-apathetic group(MAES score ≤14,75 cases).The clinical data and imaging markers were compared between the two groups.Results The apathetic group had significantly older age and larger ratio of hypertension,but shorter years of education and lower MAES score than the non-apathetic group(P＜0.05,P＜0.01).The apathetic group also had notably higher Fazekas score of white matter hyperintensity(WMH),larger recent small sub-cortical infarct(RSSI),lacunar infarct(LI),and perivascular space(PVS)in the basal ganglia and the centrum semiovale,more obvious cerebral atrophy and cerebral microbleed(CMB),and high-er total imaging burden score when compared with the non-apathetic group(P＜0.01).In the aCSVD patients,the MAES score was positively correlated with WMH Fazekas score,RSSI,LI,basal ganglia PVS,centrum semiovale PVS,cerebral atrophy,CMB,and total imaging burden score(P＜0.01).WMH Fazekas score was an independent risk factor for apathy in the aCSVD patients(OR=2.218,95％CI:1.343-3.664,P=0.002).Conclusion The higher the score of ima-ging markers in patients with aCSVD,the more severe the apathy.
