Exploration of clinical features and prognostic factors of ocular adnexal mucosa-asso-ciated lymphoid tissue lymphoma
10.12354/j.issn.1000-8179.2025.20250477
- VernacularTitle:眼附属器黏膜相关淋巴组织淋巴瘤的临床特征及预后因素探究
- Author:
Zhou MENGTE
1
;
Zhang XIAOHUI
;
Chen PING
;
Zhang JI
;
Li BINGZONG
Author Information
1. 苏州大学附属第二医院血液科(江苏省 苏州市 215004)
- Publication Type:Journal Article
- Keywords:
ocular adnexal lymphoma(OAL);
mucosa-associated lymphoid tissue lymphoma(MALT);
prognosis;
risk factors;
survival analysis
- From:
Chinese Journal of Clinical Oncology
2025;52(11):571-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In this study,we aimed to explore the clinical features and factors affecting prognosis by collecting data from patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma(OAML).Methods:Clinical data of 54 patients diagnosed with ocular ad-nexal lymphoma(OAL)at The Second Affiliated Hospital of Soochow University between September 2010 and October 2024 were retro-spectively analyzed.Of these,39(72.2%)had mucosa-asso-ciated lymphoid tissue(MALT)lymphoma,which constituted the focus of this study.The Kaplan-Meier method was used to estimate the progression-free survival(PFS)and overall survival(OS)rates.The Log-rank test was applied to compare survival differences across pathological types and treatment groups.Correlation analysis and univariate Cox regres-sion were conducted to assess the impact of various factors on PFS.Variables with P<0.050 were subsequently included in multivariate Cox regression analysis to identify independent risk factors.Results:Among the 39 patients,the median age at onset was 64 years.Thirty-two and seven patients had unilateral orbital involvement and bilateral orbital involvement,respectively.All the patients underwent surgery.After surgery,the 5-year PFS and the 5-year OS of patients with MALT lymphoma were 54.21%and 100%,respectively.Univariate Cox re-gression analysis indicated that lesion location(P=0.011,hazard ratio[HR]=0.07),remission status after the first treatment(P<0.001,HR=0.082),and EBV infection(P=0.011,HR=0.207)significantly affected PFS.Multivariate regression analysis showed that remission status after the first treatment(P=0.034,HR=0.193)was an independent risk factor for prognosis.Patients who had not achieved complete re-sponse(CR)had a worse prognosis.Conclusions:Remission status after the first treatment is an important prognostic indicator in patients with MALT lymphoma.Close follow-up should be performed for patients who have not achieved complete remission after the first treat-ment.
