Enlarged perivascular spaces in different regions of acute ischemic stroke:analysis of 172 patients
10.3969/j.issn.1009-0126.2025.05.019
- VernacularTitle:急性缺血性脑卒中不同区域血管周围间隙扩大的临床研究
- Author:
Lifang MA
1
;
Yan LI
;
Li ZHOU
;
Xiao HAN
;
Jiaxin JIN
;
Weiwei ZHANG
;
Ying GAO
Author Information
1. 100700 北京中医药大学东直门医院脑病科
- Publication Type:Journal Article
- Keywords:
brain infarction;
cerebral small vessel diseases;
perivascular spaces;
neuroimaging;
root cause analysis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(5):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristic influencing factors for enlarged perivascular spaces(EPVS)in different regions of acute ischemic stroke(AIS)patients and explore their un-derlying pathogenesis.Methods A total of 172 AIS patients admitted to our department from September 2020 to September 2023 were consecutively enrolled.According to the distribution of EPVS,they were divided into basal ganglia EPVS group(n=103)and non-basal ganglia EPVS group(n=69),as well as centrum semiovale EPVS group(n=77)and non-centrum semiovale EPVS group(n=95).General information,NIHSS score at onset,TOAST classification,fasting blood glucose,liver function,coagulation function,and homocysteine(Hcy)level were collected in all the patients.Multivariate logistic regression analysis was used to identify independent influen-cing factors for EPVS in different regions.Results The basal ganglia EPVS group had significant-ly advanced age and larger proportion of hypertension than the non-basal ganglia EPVS group,while the centrum semiovale EPVS group had smaller proportion of hyperhomocysteinemia,and larger ratios of smoking and alcohol consumption,higher alanine aminotransferase(ALT)level,and longer thrombin time than the non-centrum semiovale EPVS group(P＜0.05,P＜0.01).Mul-tivariate logistic regression analysis showed that hypertension(OR=2.093,95％CI:1.045-4.192,P=0.037)and age(OR=1.071,95％CI:1.016-1.130,P=0.011)were independent influ-encing factors for basal ganglia EPVS,while alcohol consumption(OR=2.418,95％CI:1.097-5.330,P=0.029)and thrombin time(OR=1.593,95％CI:1.129-2.249,P=0.008)were inde-pendent influencing factors for centrum semiovale EPVS.Conclusion EPVS in different regions of AIS patients are associated with distinct risk factors.Age and hypertension are primary influen-cing factors for basal ganglia EPVS,while alcohol consumption and prolonged thrombin time are significant factors for centrum semiovale EPVS.
