Relationship between CTP parameters in regions of diffusion abnormalities and disease type,severity and prognosis in elderly patients with AIS
10.3969/j.issn.1009-0126.2025.05.007
- VernacularTitle:灌注异常区CT灌注参数与老年急性缺血性脑卒中疾病分型和严重程度及预后的关系
- Author:
Haoran YANG
1
;
Xueqin ZHANG
1
;
Wei CAO
1
Author Information
1. 221000 徐州市第一人民医院影像中心
- Publication Type:Journal Article
- Keywords:
perfusion imaging;
ischemic stroke;
prognosis;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(5):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between quantitative parameters of CT perfu-sion imaging in regions of diffusion abnormalities and disease type,severity and prognosis in eld-erly patients with acute ischemic stroke(AIS).Methods A total of 293 elderly AIS patients diag-nosed and treated in our hospital from August 2021 to August 2024 were retrospectively recruited in this study.According to the TOAST(Trial of ORG 10172 in Acute Stroke Treatment)classifi-cation,they were classified into large artery atherosclerosis(LAA)type(111 cases),cardioembo-lism(CE)type(100 cases),and small artery occlusion(SAO)type(82 cases).Based on their NIHSS score at admission,they were also divided into mild,moderate and severe stroke groups(103,90 and 100 cases,respectively).Depending on modified Rankin scale(mRS)score,they were divided into good(98 cases)and poor prognosis groups(95 cases).The relationships of quantita-tive parameters of CT perfusion imaging in regions of diffusion abnormalities(cerebral blood flow,cerebral blood volume,mean transit time and peak time)with disease type,severity and prognosis were analyzed,and ROC curve was drawn to analyze the predictive value for patient prognosis.Results There were significant differences among the patients with LAA,SAO and CE types in terms of cerebral blood flow,cerebral blood volume,mean transit time and peak time(P＜0.01).The patients of CE type had obviously lower cerebral blood flow and cerebral blood volume,and longer mean transit time and peak time than those of LAA and SAO types(P＜0.05).Pearson correlation analysis showed that NIHSS score was negatively correlated with cere-bral blood flow and cerebral blood volume(r=-0.446,P=0.012;r=-0.439,P=0.015),and positively with mean transit time and peak time(r=0.512,P=0.004;r=0.478,P=0.008).Lower cerebral blood flow and cerebral blood volume,and longer mean transit time and peak time were observed in the poor prognosis group than the good prognosis group(P＜0.01).The AUC value of cerebral blood flow,cerebral blood volume,mean transit time,and peak time in predicting prog-nosis was 0.751,0.764,0.733,and 0.724,respectively,and the value of the four indicators com-bined together was 0.902,which was better than that of each indicator alone(P＜0.05).Conclu-sion There exist significant differences in quantitative parameters of CT perfusion imaging in re-gions of diffusion abnormalities in elderly AIS patients with different TOAST types,disease se-verity and prognosis.These parameters can be used as important reference indicators in assess-ment of disease type,severity and prognosis of elderly AIS patients.
