Advances in radiotherapy for first-line treatment of newly diagnosed advanced esophageal squamous cell carcinoma
10.12354/j.issn.1000-8179.2025.20250487
- VernacularTitle:放疗在初诊晚期食管鳞癌一线治疗中的应用研究进展
- Author:
Zeng HAI
1
;
Wang XIAOFENG
;
Bai HUI
;
Zhang WEIJIA
;
Cai JUN
;
Yuan ZHIYONG
Author Information
1. 长江大学附属第一医院肿瘤科(湖北省 荆州市 434000)
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma(ESCC);
radiotherapy;
immunochemotherapy;
comprehensive treatment
- From:
Chinese Journal of Clinical Oncology
2025;52(11):582-587
- CountryChina
- Language:Chinese
-
Abstract:
Owing to the insidious onset and limited awareness of early screening,many patients with esophageal squamous cell carcinoma(ESCC)are diagnosed at an advanced stage.Immunochemotherapy is the current standard first-line treatment for advanced ESCC;however,survival outcomes remain suboptimal.Radiotherapy,with its precise local control and potential immunomodulatory effects,is anticipated to act synergistically with immunochemotherapy,offering a novel direction for overcoming survival limitations.This review systematically sum-marizes the progress in the use of radiotherapy as a first-line treatment for advanced ESCC and discusses the synergistic mechanisms,clinical applications,and challenges associated with its combination with immunochemotherapy.
