Research progress on the cGAS-STING signaling pathway in glioma
10.12354/j.issn.1000-8179.2025.20250607
- VernacularTitle:cGAS-STING信号通路在胶质瘤中的研究进展
- Author:
Zhang YUBO
1
;
Zhang HUILIN
;
Tian GUOPENG
;
Liu KAI
;
Pan YAWEN
Author Information
1. 兰州大学第二临床医学院(兰州市 730000);兰州大学第二医院神经外科
- Publication Type:Journal Article
- Keywords:
cGAS-STING signaling pathway;
glioma;
STING agonist;
nano-delivery system;
immune microenvironment
- From:
Chinese Journal of Clinical Oncology
2025;52(11):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is the most common primary malignant brain tumor in the adult population,characterized by high incidence and low sur-vival rates.Current standard treatment options exhibit limited efficacy.In recent years,the crucial role of cGAS-STING signaling in tumor im-munity has garnered significant attention.This article systematically reviews the molecular mechanisms of cGAS-STING signaling in glioma and its potential tumor-suppressive effects,providing an in-depth exploration of various STING agonists and their delivery systems targeting this pathway.This review also summarizes the synergistic effects of combining cGAS-STING pathway activation with radiotherapy,chemo-therapy,and immune checkpoint inhibitors,providing substantial references for the development of multimodal comprehensive treatment strategies.
