Correlation between remnant cholesterol and contrast-induced acute kidney injury in elderly diabetes patients with ACS after PCI
10.3969/j.issn.1009-0126.2025.07.003
- VernacularTitle:残余胆固醇与老年急性冠状动脉综合征合并糖尿病患者造影剂诱导的急性肾损伤的相关性
- Author:
Jingkun JIN
1
;
Xishen ZHANG
;
Jiahui DING
;
Linsheng WANG
;
Xudong ZHANG
;
Ruoshui LI
;
Tongda XU
;
Wenhua LI
Author Information
1. 221006 徐州医科大学附属医院心内科;徐州医科大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
acute kidney injury;
contrast media;
acute coronary syndrome:remnant cholesterol
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(7):841-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between remnant cholesterol level and CI-AKI in elderly patients with ACS and concomitant T2DM following PCI.Methods A retrospective case-control study was conducted on 759 elderly T2DM patients with ACS undergoing PCI in the Affi-liated Hospital of Xuzhou Medical University between January 2020 and December 2023.The pa-tients were randomly allocated into a training group(n=608)and a validation group(n=151)in a ratio of 8∶2.Based on CI-AKI diagnostic criteria,the training group was further stratified into a CI-AKI subgroup(n=95)and a non-CI-AKI subgroup(n=513).Multivariate logistic regression analysis was used to identify the independent risk factors for CI-AKI.Results The remnant cho-lesterol level was significantly higher in the CI-AKI subgroup than the non-CI-AKI subgroup[0.78(0.51,1.07)mmol/L vs 0.57(0.40,0.81)mmol/L,P＜0.01].Red blood cell count,remnant cholesterol,age,uric acid,log-transformed systemic immune-inflammatory(SII)index,and cysta-tin C were identified as independent predictors for CI-AKI in T2DM patients with ACS after PCI(P＜0.01).ROC curve analysis demonstrated that the model combining remnant cholesterol with other independent predictors exhibited superior discriminative performance in both the training group(AUC=0.818,95％CI:0.773-0.863)and validation group(AUC=0.787,95％CI:0.686-0.889)when compared to the models excluding remnant cholesterol(P＜0.01).Conclusion Rem-nant cholesterol is an independent predictor of CI-AKI in elderly patients with ACS and T2DM af-ter PCI.A risk prediction model based on remnant cholesterol and other independent risk factors demonstrates enhanced predictive performance for postoperative CI-AKI in the patients.
