Predictive value of serum Lp-PLA2 level for high-risk coronary plaques in elderly males
10.3969/j.issn.1009-0126.2025.07.002
- VernacularTitle:血清脂蛋白相关磷脂酶A2水平对老年男性冠状动脉高风险斑块的预测价值
- Author:
Jinjin CUI
1
;
Keyu WANG
;
Xinwei CHANG
;
Fang LI
;
Hongxiang YAO
;
Xue ZHENG
;
Jian ZHAO
;
Guanzhong LIU
;
Xinjiang WANG
Author Information
1. 100853 北京,解放军总医院第二医学中心放射诊断科
- Publication Type:Journal Article
- Keywords:
1-alkyl-2-acetylglycerophosphocholine esterase;
homocysteine;
coronary disease;
fore-casting;
high-risk plaques
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(7):836-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum lipoprotein-associated phospholipase A2(Lp-PLA2)for predicting high-risk coronary plaques in elderly males.Methods A retrospective study was conducted on 46 elderly males aged ≥60 years undergoing health check-ups and coro-nary computed tomography angiography in our hospital between May and July 2024.Their general clinical data were collected.Artificial intelligence software was used to analyze coronary calcium scores and plaque characteristics.The participants were divided into a high-risk plaque group(n=15)and a non-high-risk plaque group(n=31).The differences were compared between the two groups.Multivariate logistic regression analysis was used to identify the influencing factors for high-risk coronary plaques.ROC curve was plotted to determine the predictive value of serum Lp-PLA2 for high-risk plaques,and its AUC value was calculated.Results The high-risk plaque group had significantly larger proportions of smoking history and hyperlipidemia,and higher level of homocysteine and Lp-PLA2 than the non-high-risk plaque group(P＜0.05,P＜0.01).Multiva-riate logistic regression analysis indicated that Lp-PLA2 was an independent risk factor for high-risk coronary plaques(HR=1.030,95％CI:1.008-1.053,P＜0.05).ROC curve analysis revealed that the AUC value of Lp-PLA2 in predicting high-risk coronary plaques was 0.833(95％CI:0.694-0.927,P＜0.01),with a sensitivity of 93.3％,a specificity of 71.0％,a positive predictive value of 62.5％,and a negative predictive value of 100％.Conclusion Serum Lp-PLA2 is of signif-icant value in predicting high-risk coronary plaques in elderly men.
