Effect of high-density lipoprotein cholesterol to total cholesterol ratio on no-reflow in elderly patients after interventional treatment
10.3969/j.issn.1009-0126.2025.07.007
- VernacularTitle:高密度脂蛋白胆固醇与总胆固醇比值对老年ACS合并糖尿病患者介入治疗后无复流的影响
- Author:
Na WANG
1
;
Hao WANG
;
Fan ZHANG
;
Guangyuan GUO
;
Liangfei FENG
;
Zheng REN
;
Guanglei LI
Author Information
1. 066600 秦皇岛市第二医院心内二科
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
diabetes mellitus;
cholesterol,HDL
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(7):863-866
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of the ratio of high-density lipoprotein cholesterol(HDL-C)/total cholesterol(TC)on no-reflow after percutaneous coronary intervention(PCI)in elderly patients with acute coronary syndrome(ACS)complicated with diabetes mellitus(DM).Methods A retrospective analysis was conducted on 206 elderly ACS patients complicated with DM undergoing PCI in our hospital from January 2018 to August 2024.The HDL-C and TC levels were detected by cholesterol oxidase test,and the HDL-C/TC ratio was calculated.Coronary angi-ography(CAG)was applied to evaluate no-reflow phenomenon after PCI,and according to the re-sults,the patients were divided into a non-reflow group(41 cases)and a normal reflow group(165 cases).ROC curve was plotted to evaluate the predictive performance of HDL-C/TC ratio for no-reflow after PCI in patients with ACS complicated DM.Results The no-reflow group had signifi-cantly higher TC and glycated hemoglobin A1c(HbA1c)levels and more balloon dilatations,but lower HDL-C level and HDL-C/TC ratio than the normal flow group(P＜0.01).Multivariate lo-gistic regression analysis showed that HbA1c(OR=3.196,95％CI:1.619-6.310,P=0.001),number of balloon dilatations(OR=3.504,95％CI:1.807-6.797,P=0.000),and HDL-C/TC ra-tio(OR=3.927,95％CI:2.0 73-7.441,P=0.000)were influencing factors of no-reflow after PCI in patients with ACS and DM.The AUC value of HDLC,TC,and HDL-C/TC ratio in predicting no-reflow after PCI was 0.842,0.726,and 0.922,respectively.Conclusion HDL-C/TC ratio is an influencing factor for no-reflow in patients with ACS and DM after PCI.The ratio at a cut-off val-ue of ≤0.21 has a certain predictive value for no-reflow after PCI in these elderly patients.
