Efficacy and safety of Xuezhikang Capsule combined with low-dose statin therapy in treatment of carotid atherosclerotic plaques
10.3969/j.issn.1009-0126.2025.07.008
- VernacularTitle:血脂康联合低剂量他汀类药物治疗颈动脉粥样硬化斑块患者的有效性和安全性观察
- Author:
En ZHOU
1
;
Yehua TANG
;
Jian'ou XU
;
Liping CHEN
Author Information
1. 310053 杭州,浙江中医药大学;青田县中医医院内科
- Publication Type:Journal Article
- Keywords:
Xue Zhi Kang Jiao Nang;
plaque,atherosclerotic;
cholesterol,LDL;
atorvastatin;
alanine transaminase
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(7):867-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of combined Xuezhikang Capsule with low-dose statin for patients with atherosclerotic plaques in carotid arteries.Methods A total of 240 inpatients and outpatients with carotid atherosclerosis admitted in Qingtian County Hospital of Traditional Chinese Medicine from May 2022 to March 2023 were recruited,and randomly divided into a control group and an observation group,with 120 patients in each group.The control group was given oral administration of atorvastatin,while the observation group was given same dose of atorvastatin in combination with Xuezhikang Capsule.The clinical efficacy,blood lipids before and after treatment,and safety were compared between the two groups.Results The LDL-C levels at 8 and 24 weeks after treatment were significantly lower in the observation group than the control group(P＜0.05,P＜0.01).The change in LDL-C level in the observation group was obviously higher than that of the control group after treatment(P＜0.05).The alanine transaminase level was notably lower in the observation group than the control group after 24 weeks of treatment(26.74±7.66 U/L vs 31.53±10.18 U/L,P＜0.01).There was no statistical difference in the inci-dence of adverse reactions between the two groups(P＞0.05).Conclusion In the treatment of pa-tients with carotid atherosclerosis,Xuezhikang Capsule combined with low dose of statin can re-duce blood lipid with high safety.
