Research advances on ferroptosis in gastric cancer
10.12354/j.issn.1000-8179.2025.20250516
- VernacularTitle:铁死亡在胃癌中的研究进展
- Author:
Yu ZHEN
1
;
Wang HAIJIANG
1
Author Information
1. 新疆医科大学附属肿瘤医院胃肠外科一病区(乌鲁木齐市 830011)
- Publication Type:Journal Article
- Keywords:
gastric cancer;
ferroptosis;
non-coding RNA;
tumor microenvironment
- From:
Chinese Journal of Clinical Oncology
2025;52(13):692-696
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a newly recognized form of regulated cell death(RCD)associated with iron accumulation and lipid peroxidation.Ferroptosis involves biological and pathophysiological processes distinct from those of apoptosis,autophagy,and necroptosis.Ferroptosis has attracted worldwide attention since its discovery in 2012.It is involved in the progression of various diseases and may be a novel thera-peutic target.In recent years,major advances in research into ferroptosis in gastric cancer have revealed that the occurrence of ferroptosis is cooperatively regulated by factors including non-coding RNAs(miRNAs/lncRNAs/circRNAs),the tumor microenvironment,and Helicobacter pylori.Numerous studies have shown that ferroptosis plays an important role in gastric cancer cell proliferation,metastasis,drug resistance,and microenvironmental remodeling.This study reviews ferroptosis mechanisms and its role in the development and progression of gastric cancer,offering new therapeutic insights for clinical treatment.
