Advances in the application of 18F-FDG PET/CT radiomics in non-small cell lung cancer
10.12354/j.issn.1000-8179.2025.20250802
- VernacularTitle:18F-FDG PET/CT影像组学在非小细胞肺癌中的应用进展
- Author:
Fu QIANRU
1
;
Liu JINSONG
Author Information
1. 河南中医药大学针灸推拿学院(郑州市 450003)
- Publication Type:Journal Article
- Keywords:
18F-fluorodeoxyglucose(18F-FDG);
positron emission tomography/computed tomography(PET/CT);
non-small cell lung can-cer(NSCLC);
radiomics;
therapeutic decision-making;
prognostic assessment
- From:
Chinese Journal of Clinical Oncology
2025;52(13):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer(NSCLC)is the leading cause of cancer-related morbidity and mortality worldwide and is the most pre-valent thoracic malignancy in China.With regards to the diagnosis and treatment of NSCLC,advances in radiomics have enabled the high-throughput extraction and quantification of intratumoral spatial heterogeneity.18F-fluorodeoxyglucose positron emission tomography/com-puted tomography(18F-FDG PET/CT),which integrates high-resolution anatomical details with functional metabolic data,has been widely used in oncologic imaging.By synergistically combining 18F-FDG PET/CT with radiomics to construct machine learning models,the clinical util-ity of this modality has markedly expanded,and it has been rapidly integrated into the comprehensive management of lung cancer.In the diagnostic setting,these integrated models can differentiate benign from malignant pulmonary nodules with high reliability,thereby enhan-cing the accuracy of early stage NSCLC detection and enabling a non-invasive prediction of histopathologic subtypes.Radiomics signatures can also provide robust support for precision oncology by facilitating accurate TNM staging,predicting actionable genomic alterations,and estimating immune checkpoint expression levels.Moreover,machine learning-based radiomic analyses are valuable in treatment response monitoring and prognostication,effectively forecasting therapeutic efficacy and patient survival outcomes.In this review,we summarize re-cent advances in the application of 18F-FDG PET/CT radiomics across the entire continuum of NSCLC care.
